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burgdorferi lacks virulence factors common to many microbial and bacterial pathogens, such as specialized secretion systems, toxins, or extracellular proteases with the exception of HtrA [Citation15,Citation155]

Several herbs and formulations, including licorice ( Glycyrrhiza glabra ), peppermint ( Mentha piperita ) oil, turmeric ( Curcuma longa ), and Triphala, have shown consistent clinical and experimental efficacy, supporting their relevance in both symptom relief and disease modification

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The use of mice lacking NKCC1 specifically in insulin-secreting -cells (NKCC1 KO ) has provided some insight into the long-term metabolic effects of the bumetanide-sensitive NKCC1 in insulin secreting cells